منابع مشابه
Mechanisms of Vascular Insulin Resistance
Insulin resistance is characterized by the diminished ability of insulin to initiate intracellular signaling. It is a common manifestation of obesity and a prelude to type 2 diabetes. The primary targets of insulin are skeletal muscle, adipose, and the liver. Impaired insulin signaling in these tissues reduces glucose uptake and promotes a metabolic syndrome that is characterized by elevated le...
متن کاملCharacterization of the insulin resistance of aging.
To clarify the nature of the insulin resistance of aging we studied the dose response for insulin-induced glucose disposal and the binding of insulin to circulating monocytes in healthy young and old men. A total of 49 two-hour euglycemic insulin clamp studies were performed in 17 young and 10 old healthy nonobese subjects. While the old group had lower estimates of lean body mass and greater e...
متن کاملReview of Mechanisms and Theories of Aging
Several factors have incentive role for study of aging which includes increasing of the average and maximum of human life span, the increase in percentage of elderly in the societies and proportion of the national expenditure utilized by them. The Recent views of aging indicating that aging is extremely a complex multifactorial process despite of earlier views about definite cause aging like ge...
متن کاملMechanisms of insulin resistance in cystic fibrosis.
Cystic fibrosis (CF) is associated with a high incidence of diabetes. Studies evaluating causes of CF-related diabetes (CFRD) have consistently documented decreased insulin secretion. In patients with CFRD, insulin sensitivity has been documented to be decreased, but controversy exists in patients with normal or impaired glucose tolerance (IGT). We undertook this study 1) to reexplore insulin s...
متن کاملAging and Insulin Resistance: Just Say iNOS
The ubiquitous presence of insulin resistance cannot be understated. First brought to light by Himsworth and Kerr (1) in 1939, insulin resistance, defined as a subnormal response to a given dose of insulin, was ushered into prime time by Gerald Reaven (2), where it has remained at center stage. Insulin resistance is a major feature of type 2 diabetes (2). Insulin resistance is also associated w...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1983
ISSN: 0021-9738
DOI: 10.1172/jci110908